Predictive factors of poor outcome in road traffic injures; a retrospective cohort study.

INTRODUCTION
Road traffic injuries (RTI) are among the most important health problems worldwide as they cause more than 1.2 million deaths and 50 million injuries each year. Therefore, the present study aims to evaluate the outcome and aftermath of RTI in those who were injured and hospitalized due to a traffic accident.


METHODS
In the present retrospective cohort study with a one-year follow-up, data were extracted from the profiles of the RTI hospitalized patients. Outcome of the patients was evaluated at the time of discharge and 1-year later including their living state, presence of a disability or complete recovery.


RESULTS
1471 patients were studied (mean age of 32.8±17.0; 80.3% male). 571 (38.8%) had mild disability, 684 (46.5%) moderate disability, and 85 (5.8%) had severe disability at the time of discharge. In the end, 53 (3.6%) died. In the 1-year follow-up, 194 (13.2%) had mild disability, 43 (2.9%) had moderate disability, 9 (0.6%) had severe disability, and 7 (0.5%) were in a vegetative state. Presence of an underlying disease (p=0.03), loss of consciousness for more than 24 hours (p=0.04), spinal injury (p=0.002), presence of multiple trauma (p=0.01), increased ISS (p<0.001), need for ventilator (p<0.001), and organ injuries during hospitalization (p<0.001) are independent factors that increase the risk of poor outcome in RTI patients.


CONCLUSION
Based on the results of the present study, underlying illnesses, loss of consciousness for more than 24 hours, spinal injury, multiple trauma, increased ISS, need for ventilator, and organ injuries during hospitalization were independent factors that increased the probability of poor outcome in RTI injuries.


Introduction
Road traffic injuries (RTI) are among the most important health problems worldwide as they cause more than 1.2 million deaths and 50 million injuries each year. More than 90% of mortalities due to RTI occur in low and middle income countries (1,2). It is predicted that in the next 5 years RTI will lead to 6 million deaths and 60 million injuries, only in developing countries. In 1990, RTI ranked 9 t h in the most important factors determining population health and it is pre-dicted to become the 3 r d cause of mortality and disability by 2020. The reports also show that 50% of the dead were 15-43 years old, who are the most effective population in a society's financial development (3). In Iran RTI rate is very high and fatal RTI rate is 33 in 100000 people, which emphasizes the need for more research and taking preventive measures and efficient treatment in managing RTI (4)(5)(6). The high social and financial costs of RTI and its physical and mental aftermaths on people and societies are the major problem that transportation managers and health providers must face. This challenge is many times more in developing countries, where RTI rate is increasing and its direct and indirect costs are more than the developed countries. World Bank report shows that the number of people who die of RTI in Iran has increased by 10%, which is higher than most developing Search terms

Death
Severe injury or death without recovery of consciousness 2. Persistent vegetative state Severe damage with prolonged state of unresponsiveness and a lack of higher mental functions 3. Severe disability Severe injury with permanent need for help with daily living 4.

Moderate disability
No need for assistance in everyday life, employment is possible but may require special equipment.

mild disability
Light damage with minor neurological and psychological deficits.

Good recovery
Resumption of normal activities, however there may be minor neurological or psychological deficits.
countries and is very undesirable and worrisome compared to world standards (2). In its last report, World Health Organization has expressed the need for more research on the epidemiologic pattern of RTI in low and middle income countries to determine the dimensions of the problem and identify those who are most susceptible to RTI, since no accurate estimation exists regarding the social and economic effects of RTI in these countries. Although valuable efforts have been made to identify the effects and outcomes of RTI in Iran in recent years, there is still a shortage of available data in this regard (7)(8)(9). Therefore, the present study aims to retrospectively evaluate the outcome and aftermath of RTI in those who were injured and hospitalized due to a traffic accident.

Study design
The present study is a retrospective cohort one, with a oneyear follow-up, carried out in two educational hospitals in Tehran, Iran. Patients referred to the hospitals from April 2012 to March 2013 were included and Ethics Committee of Shahid Beheshti University of Medical Sciences approved the study. Data collection forms were anonymous and patient data remained confidential.

Participants
The studied population consisted of all the patients injured in RTI during the course of the study, who had an accident with at least 1 vehicle. Patients with incomplete or unreachable data were excluded. There was no age and sex limitation.

Data collection
Data collection was done using a checklist that consisted of demographic data (age, sex, level of education), trauma mechanism, type and location of injury, type of vehicle in accident, route of transportation to emergency department (ED) (by ambulance, taxi, or personal vehicle), pre-hospital clinical measures taken, hospitalization status, hospitalization duration, intensive care unit admission, injury severity score (ISS), need for ventilator, organ failure, and outcome (death, disability, or complete recovery at the time and one year after discharge). Data were gathered by trained emergency medicine residents. Their trainings consisted of research tool management (how to fill a checklist, data recording) and summarizing medical data. Data were extracted from the patients' profiles and quality of data collection was evaluated by the head researcher of each hospital every 24 hours. In addition, at the end of each week, some checklists were randomly chosen and their quality was controlled by the chief researcher to ensure the quality of data collection. In this study, injury severity was classified into 4 groups: mild (ISS < 9), moderate (ISS 9-15), severe (ISS 16-25), and profound (ISS > 25).

Outcomes
Living status (dead or alive), and disability or complete recovery at the time of discharge were appraised, and in-hospital complications such as embolism, deep vein thrombosis, infection, organ failure, need for ventilator, infection, high or low blood pressure, hypothermia, hypoxia, seizure, sepsis and shock were evaluated. Death and severe disability were considered as poor outcome. Glasgow outcome scale (GOS) was used for the 1-year follow-up outcome evaluation (panel 1). GOS divides patients into 2 groups based on desirable and undesirable outcome: poor consisting of GOS score 1-3 and desirable with the score of 4-6. In the 1-year follow-up, the patients or their relatives were contacted by phone. Cases that could not be contacted after calling 3 times (due to not responding, wrong number or the phone number being sold) were considered as loss to follow-up.

Statistical analyses
Data were analyzed using STATA 11.0. Quantitative data were reported as mean and standard deviation, and qualitative ones as frequency and percentage. Outcome (death, disability, complete recovery) and complications were assessed based on demographic data, baseline characteristics and clinical information. The association of each variable with 1-year outcome was then determined using independent t-test, chi square and exact Fisher's test. Finally, to assess the independent predictive factors of patient outcome, stepwise multivariate logistic regression analysis was used. In all analyses, p < 0.05 was considered as significance level.

Univariate analyses
Higher ages (p < 0.001); being referred from another hospital (p = 0.001); high energy trauma mechanism (p = 0.03); having a history of myocardial infarction (p = 0.009), cerebral vascu- 0.99 *, Some patients have more than one injury or underwent more than one procedure.

Multivariate analyses
Presence of an underlying illness (p = 0.03), loss of consciousness for more than 24 hours (p = 0.04), spinal injury (p = 0.002), presence of multiple trauma (p = 0.01), increased ISS (p < 0.001), need for ventilator (p < 0.001), and organ failure during hospitalization (p < 0.001) were independent factors that increased the risk of poor outcome in RTI patients. In contrast, a single abdominal trauma (p = 0.006) and hospitalization in ICU were associated with improved outcome (Table 4).

Discussion:
The present study showed that young males are most frequently affected with RTI and motorcycle is the most important cause, which is in line with previous studies. For instance, Yousefzadeh et al. showed that the number of men involved in RTI was 3.6 times the women, and about 50% of the patients were 20-44 years old. Most injuries were due to motorcycle accidents and 5.2% died in the end (10). Torabi et al. also revealed that 89.9% of the injured were male and mostly (56.8%) 16-25 years old (11). In another cross-sectional study in Tehran, most of those injured in RTI were 21-30 years old (22.3%), and mainly pedestrians (54.6%) (12). Hatamabadi et al. also expressed that majority of those who were killed in traffic accidents were male, most of which were 21-40 years old and uneducated (13). These researchers, in an-other study, reported 7.0% mortality rate due to RTI. 78.5% male and the majority aged 20-30 years old and most used personal cars (52.9%) (14). This higher mortality rate was due to the nature of the road they studied. Abali-Tehran is an inter-city road in Iran that has steep slopes and can be very slippery especially in rainy seasons. In addition, driving speed is much higher compared to urban streets and there are fewer motorcycles, which might justify the low rate of motorcycle accidents. In the present study, mortality due to RTI was 3.05%. Akbari et al. studied RTI in 10 provinces of Iran and concluded that mortality rate in unintentional accidents was 4% which is in line with this study. Traffic accidents with 7.51% were the most frequent cause of death (15 (11). A study by Kadivar et al. also showed that RTI was the major cause of death in unintentional accidents (16). Despite RTI being the third most important cause of death, since it targets the younger population (mean age was about 34 years in 2001), it ranks first in the list of causes for years of potential life lost (6,17). Controlling and decreasing RTI is not the responsibility of health care providers but informing the responsible organizations on the importance of this problem and cooperating with them to control and reduce this major cause of death can be. The statistics of this study reveal the necessity of paying more attention to emergency services and providing trauma centers and equipping them. The reason for high mortality rate of RTI and its increase might be industrialization and broader usage of motor vehicles in recent years without improving standards for this new way of life. Reducing drug abuse, safety education, improving protective measures in working environment, rapid first aid in the location of accident, eliminating causing factors (reducing speed, putting appropriate signs on the road, etc), enforcing more restricted traffic rules, and providing rehabilitation services are among the useful measures, which can aid in prevention of accidents and therefore decrease mortality. The findings of logistic regression analysis showed that presence of an underlying illness, loss of consciousness for more than 24 hours, spinal injury, presence of multiple trauma, increased ISS, need for ventilator, and organ injuries during hospitalization were independent factors that increased the risk of poor outcome in RTI patients, while a single abdominal trauma and hospitalization in ICU led to improved final outcome. These results emphasize the importance of careful evaluation of these patients in ED, so that no injury goes unnoticed, because if the injuries are rapidly diagnosed and properly treated outcome can improve (18,19). This is confirmed by the result of this study that states hospitalization in ICU leads to improved outcome. Therefore, paying attention to these patients and maintaining proper tissue perfusion during hospitalization can prevent organ disabilities and therefore poor outcome.

Conclusion:
Based on the results of present study, underlying illnesses, loss of consciousness for more than 24 hours, spinal injury, multiple trauma, increased ISS, need for ventilator, and organ injuries during hospitalization were independent factors that increased the probability of poor outcome in RTI injuries.